In the mid-1990s, Cartoon Network launched a show based on animated shorts by various creators and animators, and it would lead to many popular animated series.
What a Cartoon! Debuted on February 20th, 1995 with a short called “The Powerpuff Girls: Meat Fuzzy Lumpkins” created by Craig McCracken. This first short would lead to a successful series that lasted six seasons, and even got a theatrical movie. Many talents from that series would go on to future success—McCracken later created Foster's Home for Imaginary Friend's and Lauren Faust would go on to create My Little Pony: Friendship is Magic.
The very next short, Dexter's Laboratory from Genndy Tartakovsky, would also become a successful series on Cartoon Network.
Other shorts that led to series included Johnny Bravo (series with same name) from Van Partible and "Courage the Cowardly Dog: The Chicken from Outer Space" (series with same name) from John Dilworth. In addition, “Larry and Steve” by Seth McFarlane is considered the G-rated prototype to the successful adult animated series Family Guy, with an intelligent dog and his clueless owner.
A future set of shorts led to series such as Mike, Lu & Og, Codename: Kids Next Door, and The Grim Adventures of Billy & Mandy.