The second most powerful man in the U.S. House has been thrown out on his ear.
Majority Leader Eric Cantor of Virginia has lost his primary re-election bid to a little-known, tea party-backed Republican challenger who ran on opposition to immigration law.
Economics professor David Brat says his stunning upset is "a miracle from God that just happened."
Cantor told supporters in they had come up short in the effort to seek an eight term representing the 7th District. It's majority Republican and includes portions of suburban Richmond.
Cantor's defeat was the first primary setback for a senior leader in Congress in recent years.
Democrats seized on the upset as evidence that their fight for House control this fall is far from over. Democratic leader Nancy Pelosi says Cantor represented extreme policies and "debilitating dysfunction."
In the fall, Brat will face Democrat Jack Trammel, also a professor at Randolph-Macon College, in suburban Richmond.
U.S. Sen. Lindsey Graham won South Carolina's Republican party outright on Tuesday, defeating six tea party challengers and avoiding a runoff.
Graham, who has been in office since 2002, had a hefty fundraising advantage: He has raised more than $12 million since his last re-election bid in 2008, while none of his opponents passed the $1 million mark.
Meanwhile, Graham's fellow Republican U.S. Sen. Tim Scott won his primary by a wide margin, setting the stage for South Carolina to elect a black person to the U.S. Senate for the first time.
Scott was appointed to the seat in 2012 after Jim DeMint stepped down, and the general election winner will serve the remainder of DeMint's term.
The Democrats had two primaries of their own, though it's widely expected that the Senate seats will remain in the GOP's hands.