Money raised during the event, which will be held July 14 at The Club, will go to the Republican National Committee Presidential Trust, which will support the campaign in battleground states.
The Alabama Republican Party said for $5,000, a couple also can have their picture taken with Mrs. Bush.
Alabama GOP Senator Jeff Sessions and Linda Maynor, the top fund-raiser for the state party, are chairing the fund-raiser.
Fellow Republican Senator Richard Shelby is the honorary chairman, and Gov. Bob Riley and the five Republicans in Alabama's House delegation are co-chairs.