The blaze at 206 Eden Court off Prevatt Road was reported about 4:20 a.m.
Several units from the Dothan Fire Department responded and found the home engulfed in flames. Firefighters quickly brought the flames under control, but the house is a total loss. At least one vehicle parked near the residence was also heavily damaged by the heat from the flames.
Police said everyone inside got out safely and no injuries were reported.
Fire officials are still trying to determine the cause of the blaze.