It happened in the Southport area off Highway 77 just south of the 388 intersection.
Florida Highway Patrol troopers are working the crash and say it happened a little after 7 pm Sunday.
Apparently the driver of silver mid sized sedan was driving north on Highway 77 when she struck and killed a man who was trying to cross the street.
Troopers believe it to be an accident, but will continue to investigate.
Investigators have not released the names of the driver or the victim.