One person has been life-flighted to a Dothan Hospital after a crash just north of Enterprise.
The accident happened around 5:15 p.m. on Highway 167 North.
It involved a pick-up truck and a small car. First responders had to use the Jaws of Life to remove passengers from both vehicles.
One person was taken by helicopter to a Dothan hospital. Another was taken to an Enterprise hospital with what appeared to be non-life threatening injuries.
Alabama State Troopers are on the scene.
Traffic on Highway 167 is currently blocked so drivers may want to find an alternate route.
The victims have not been identified.