Abbeville Police Chief Mike Jones said the arrests were made Saturday night during a traffic stop on Ala. Highway 27, near U.S. 431.
Jones said officers arrested 26-year-old Crystal Gibbs of Headland; 24-year-old Daniel Thrasher and 25-year-old Marlon Mike, both of Dothan.
The three were each charged with trafficking methamphetamine. Their bond was set at $125,000.
Jones said the pills were worth an estimated $10,000 on the streets.