Lee County Coroner Bill Harris said the accident happened Friday when 27-year-old Irene Miller of Whaleyville, Md., lost control of her vehicle, crossed into the southbound lane and struck two vehicles.
Miller was killed instantly.
The collision also killed 51-year-old Steven Williams and 49-year-old Melinda Williams of West Point, Ga.
Bystanders helped pull a 6-year-old and 10-year-old girl from their vehicle before it caught fire.
A 25-year-old man who was driving a third vehicle was also injured.
The accident temporarily closed the interstate. Police are still investigating.
(Copyright 2011 by The Associated Press. All Rights Reserved.)