Police said in a statement that officers were summoned around 8 p.m. Friday for a report of gunfire near I-59 north and the exit for 22nd Street.
Arriving police officers found two police officers were involved in a shooting with three suspects.
A male and female suspect suffered gunshot wounds and were taken to UAB Hospital for treatment.
Officials said a third suspect was taken into custody.
Police did not immediately release their identities. They were not formally charged with any crimes Saturday.
No other injuries were reported.
Birmingham police did not immediately return phone calls seeking to confirm why the two police officers were at the scene of the shooting.