The Department of Public Safety estimates that 13 people will die in roadway accidents across the state.
Last year, troopers said nine people died in holiday traffic accidents, six on rural roads and three in urban areas.
Public Safety Director, Colonel Mike Coppage, said highway checkpoints will be set up across the state in conjunction with the nationwide Click It or Ticket campaign. DUI enforcement and speed limit violations will also be closely monitored.
Coppage also said troopers will quadruple the number of patrols on the popular vacation routes, including all interstates and U.S. Highways 231 and 331.
The 78-hour holiday travel period starts tonight at 6 p.m. and ends at midnight Monday, May 31.