This time it was an abandoned apartment building behind the downtown post office that went up in flames.
The fire broke out around 11 a.m. Saturday morning in the 300 block of North Lena Street.
Just a few months ago, Dothan Fire Fighters were called to the same spot. That time flames destroyed another building on the property.
Investigators believe a homeless man who had been using the building as shelter started that fire. An investigation is continuing into the cause of this latest fire.