Someone broke into the Southern Hardware Feed and Seed Store in Cowarts between Saturday afternoon and Monday morning.
Investigators found three sets of tracks running across a field to a road behind the business. Rifles and shotguns were ignored, but 12 handguns were taken in the burglary.
Owner Wayne Folkes says nine of the weapons were brand new and three were valuable antiques.
Crimestoppers is offering a reward of up to $1,000 for information in the case. Federal authorities are assisting the sheriff's department with the investigation.
Crimestoppers Information Line 793-7000