Joanne Kurtzberg, M.D., on Blood and Marrow Transplant

Joanne Kurtzberg, M.D., director of the Pediatric Blood and Marrow Transplant Program at Duke University Medical Center, talks about the future of treatment with umbilical cord blood.

What are the benefits of public cord banks?

Dr. Joanne Kurtzberg: Public cord blood banking is a way for moms to donate their baby's cord blood for use by any patient in need who might search the national registry to find a donor. Cord blood has the advantage of not having to match as closely as adult cells, so many patients who can't ever find a fully matched adult donor can use the cord blood instead. Moms can donate in the areas where public banks have been established. Right now, the US Federal government, through a program called the C.W. Bill Young Cell Transplantation Program, funds eleven banks that are distributed around the country, and each bank has group of area of hospitals that they reach out to, to collect in.

In North Carolina, we collect at seven hospitals. In addition, there was a state law just passed that will create a website to inform moms about how to donate cord blood publicly, and will also provide moms a way to donate through a kit if their hospital doesn't support cord blood collection.

Why is it important to focus on public banking?

Dr. Kurtzberg: It's really very interesting. The public units are used many, many, many times more often than the private units and there are very few indications so far,that, using a child's own cord blood would have benefit. On the public side, there's a great need for donors and moms can give away something that otherwise would be discarded and can save somebody's life.

Where do you see the future of cord blood going?

Dr. Kurtzberg: Right now, cord blood is used for most of the same conditions that a bone marrow transplant for. That includes treating patients who have cancer, especially leukemia, sickle cell anemia or thalassemia, those who have failure of their immune system or their bone marrow to make blood cells, and occasionally children with metabolic diseases. In all those cases a donor's cells are required to correct the condition and to rescue the bone marrow from chemotherapy and or radiation.

I think in the future we're going to also see cord blood emerge as a source of cells for what is being called "cell therapy" to treat patients with heart disease, strokes, and with vascular ulcers that have trouble healing. It may also help patients with diabetes. Now when I say all this, I don't mean it's just going to work alone – it's going to work in combination with therapies that address those diseases. Here at Duke, we're piloting some studies in children with cerebral palsy and other kinds of newborn brain injuries to see if their own cord blood may help them recover from the injury, so I think the emerging field of cell therapy is going to be the next exciting use of cord blood.

Can you tell us a little bit about Max – the patient we just saw?

Dr. Kurtzberg: Max is a little boy who has cerebral palsy which he developed after he had in utero strokes, but it wasn't really discovered when he was born. As he got older, as an infant, he started to have some neurologic problems and had a scan which showed the strokes. We actually gave Max his own cord blood cells because we know from our work with children who have genetic diseases of the brain that cells go to the brain after we infuse them in the blood and that they can help repair damage in the brain. We're hoping in children with cerebral palsy that that will happen as well. There are a lot of things we don't know about it. We don't know how many cells we have to give, we really don't know if giving them in the blood is the best way to do it, and we also don't know if the age of the tot matters. It might work better if he was two months old than if he's six years old, but we are doing a study to figure all those things out.

How long will he need infusions?

Dr. Kurtzberg: He only has enough cells to have one infusion, and it will take about a year to know if it's made a difference.

What other research on neurological conditions are you working on?

Dr. Kurtzberg: This fall, we'll be embarking on a study we call a randomized trial where we'll be treating half the children enrolled with their own cells at the time we first meet them and the other half a year later, and we won't know which children got their cells at which timeframe. We're then going to evaluate them neurologically and with scans to determine whether the cells made a difference, and that will be the definitive way to be able to, we hope, prove that cells are

When you say obviously make a difference, are you talking about children improving neurologically or physically?

Dr. Kurtzberg: In children with cerebral palsy, most of them have something called spasticity, which is stiffness or inability to use an extremity or one side of their body, so we're going to look to see if their function improves after the cells are infused.

In general, do you consider cord blood a miracle liquid?

Dr. Kurtzberg: It saves lives – that part of it is miraculous.

Are you still very cautious?

Dr. Kurtzberg: Yes, and we have to really demonstrate that it helps with this kind of condition, as well as some of the others I mentioned. We do know in animals and in some of the work we've done in donor cells that cord blood cells have the potential to help various organs of the body, but we still have to learn how to do it

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  • by alvin Location: los angeles on Aug 21, 2011 at 10:07 AM
    what about the possible use of umbillical cord blood in autism?
  • by Adwoa Location: Ghana on Jul 6, 2010 at 07:07 AM
    This is really wonderful news to read. Please, how can a sickled cell child from Ghana benefit from this technology? I will be grateful if you could reply me through my email adress provided. Thank you
  • by Josephine Location: Los Angeles, CA on Jan 20, 2010 at 04:56 PM
    This is an amazing thing that all expecting parents should learn more about:
  • by Chris Location: Arizona on Jan 19, 2010 at 10:22 AM
    This is exciting stuff. It looks like it does in fact that children can benefit from their own cells. Unless I am wrong, all of her studies are looking at treating the children with their own cord blood cells. If you donate it to a public bank, can you get it back if your child needs it? I heard that most of the cord bloods get used in research so I don't think it will be there for us to get it back. I'm a little confused.
    • reply
      by alvin on Aug 21, 2011 at 10:09 AM in reply to Chris
      what about umbillical cord blood in autism?
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